Dr. Phyllis Pobee, M.D., is a triple board-certified physician and the Founder & CEO of GeneLean360°, a science-based weight loss company helping women transform their health through genetics and cellular insight.
Based in Toronto, Canada, she is certified in Family Medicine, Aesthetic Medicine, and Obesity Medicine, and is the author of Lean Genes.
Her journey began not in a lab, but in her own life. After years of doing “everything right” and still struggling with her weight, Dr. Pobee turned to genetic testing to uncover the truth behind her body’s resistance. What she discovered changed everything — her unique biology held the key. By learning how her genes influenced her metabolism, she lost 100 pounds and kept it off.
That discovery became the foundation of GeneLean360°, a 4-month holistic weight loss programme designed for women over 30. It blends genetics, mindset, and lifestyle to achieve lasting results without extreme diets or deprivation.
Dr. Pobee leads her company with a mission to help women stop fighting their biology and start working with it. She believes in “science with soul” — combining data-driven precision with empathy and education. Through GeneLean360°, she’s redefining how women view weight loss: not as punishment, but as a path to understanding their own bodies.
Her vision is simple yet profound — a world where women live in harmony with their genetics, guided by knowledge, compassion, and self-trust
Q&A with GeneLean360° Founder and Physician Leader
How did your journey into medicine and genetics begin?
I’ve always loved science and understanding how the body works. But my real turning point came when I was struggling with my own weight. I was a practising doctor, doing everything “right” — eating well, exercising — yet nothing was changing. It was humbling. Eventually, I discovered that my genetics were influencing how my body responded to food and exercise. Once I understood that, everything clicked.
What inspired you to start GeneLean360°?
After losing 100 pounds by applying genetic insights to my own life, I realised other women needed the same understanding. I founded GeneLean360° to help women stop guessing and start using science to make real progress. Many of my clients are women over 30 who’ve tried every diet imaginable. They’re not lazy or unmotivated — they’ve simply been fighting against their own biology.
Can you explain how the GeneLean360° approach works?
It begins with cellular health. We start with a simple at-home urine test to measure inflammation and oxidative stress — two key indicators of how well your body is functioning. Then we meet one-to-one to interpret the results and identify what’s blocking fat loss. If appropriate, we recommend genetic testing to map out how your DNA affects metabolism, appetite, and hormones. From there, we design a precision plan tailored to your body.
You often say “science with soul.” What does that mean?
To me, it’s about balance. Science gives us the data — the what and why — but soul gives us compassion. My work is rooted in empathy because transformation is personal. We’re not just changing numbers on a scale; we’re helping women rebuild their relationship with themselves.
How do you see the weight loss industry changing?
The industry is shifting from one-size-fits-all diets to personalised wellness. People are tired of extremes. They want solutions that fit their biology and lifestyle. Genetics is the future because it explains why two people can do the same thing and get completely different results.
What challenges did you face in building a science-based wellness business?
Educating people was the biggest hurdle. We’ve been conditioned to think weight loss is about willpower. It’s not. It’s about biology. Helping women unlearn old diet myths and embrace a more informed, compassionate approach takes time — but it’s worth it.
What do you think sets GeneLean360° apart?
We combine advanced diagnostics with emotional awareness. Most programmes focus only on food or exercise. We go deeper, looking at cellular health, hormones, stress, and even mindset. I often tell clients, “If your cells are inflamed, you can’t burn fat efficiently.” That’s the level of precision we work at.
What kind of results do your clients experience?
They don’t just lose weight — they gain clarity. Many say it’s the first time they truly understand their bodies. They stop feeling guilty for what isn’t their fault. When you see that shift — from frustration to empowerment — that’s success.
What advice do you have for women beginning their health journey?
Start by listening to your body. Pay attention to how different foods, stress, and sleep affect you. Don’t chase perfection; chase understanding. The more you learn about your biology, the more sustainable your choices become.
Where do you see GeneLean360° heading in the next few years?
I want to see genetic-based wellness become mainstream. Imagine a world where your doctor doesn’t just ask what you eat, but how your DNA processes what you eat. That’s the future — health guided by genetic truth and personalised care.
Read more:
Inside the Mind of Dr. Phyllis Pobee: The Science Behind GeneLean360°
